Aziz Ziriat, 36, and Sam Harris, 35, have not been seen since January 1, according to the Palace for Life Foundation.
The pair failed to make contact after 2.20 pm that day and missed their return flight to the UK on January 6.
They were possibly following the route shown (Image: Crystal Palace For Life)
The last known location of the two men is believed to be Casina Dosson, a hut near the town of Tione di Trento, close to Riva del Garda on Lake Garda.
The foundation, which has been a vital part of the south London community for over 30 years, posted photographs of the two men on its social media page, including one of Sam on snow-covered terrain wearing a grey top, dark trousers, a coat, and glasses.
It is possible that Sam was last wearing the outfit (Image: Crystal Palace For Life)
A diagram of the potential route the hikers might have taken was also shared.
Aziz is described as 6ft 3in tall, while Sam is 5ft 11in
The charity is urging anyone with information or potential sightings of the men to contact authorities immediately, as concern grows over their safety.
A spokesperson for the charity said: “We are urging supporters to share any information they might have to help locate Palace for Life staff member Aziz Ziriat, and his friend Sam Harris, who have been missing since 1st January whilst hiking in the Dolomites mountains in northeastern Italy.
“The two were last heard from at 14:20 on Wednesday, 1st January, and they were believed to be near a hut called Casina Dosson – near the town Tione Di Trento, near Riva Del Garda, on Lake Garda.
“We are appealing for anyone familiar with the area, who can provide assistance or information, to get in touch.
“If you know the area and can help, please dial 999 and reference CAD 0197/07 Jan25.”