The warning has been issued for London and large parts of the south of England from 12pm on Saturday (January 4) up until 9am on Monday (January 6).
Heavy snow has been forecast to hit large parts of the UK spreading in a north-eastern direction on Saturday and into Sunday.
This follows cold and frosty spells expected in London this week after strong winds hit the UK today (January 1), with a yellow weather warning in place.
It is currently unknown how much snow the UK is likely to get, but the Met Office has advised that there may be large amounts of snow, particularly on higher ground.
Southern parts of the UK may also be affected by freezing rain at times as milder air moves in, making the snowfall likely to be shorter in those areas.
Snowy weather conditions could have an impact on travel, with roads most likely to be impacted along with rail and air services.
Drivers are being advised to make extra time while travelling in the event of delays caused by snowfall.
Commuters are being advised to check before travelling over the weeknd, with further information expected over the coming days on where the snowfall is most likely to occur.